One weird thing about Republicans trying to use "open schools" as a wedge issue to get voters to turn against Democrats, is that Biden is also pushing to open schools. Another weird thing is that given the pace of vaccination, all schools are likely to be open well before the 2022 mid-term elections. People are probably going to care a lot more about other stuff by then.
It's great that some Republicans are trying to run on a policy question for once, but it is also pretty evident that they are not very good at this stuff.